Diagnostic Accuracy Study of a Novel Blood-Based Assay for Identification of Tuberculosis in People Living with HIV
Abstract
A nonsputum triage test to rule out tuberculosis (TB) disease is a WHO high-priority diagnostic, and a combinatory score based on a 3-gene host signature has shown promise in discriminating TB from other illnesses. We evaluated the accuracy of an early-prototype cartridge assay (“Xpert MTB Host Response” or Xpert-MTB-HR-Prototype) of this 3-gene signature on biobanked blood samples from people living with HIV (PLHIV) against a comprehensive microbiological reference standard (CMRS) and against Xpert MTB/RIF on the first sputum sample alone.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 18, 2021
- Source ID
- 10.1128/jcm.01643-20
Entities
People
- Anna Mantsoki
- Claudia Denkinger
- David H. Persing
- Devasena Gnanashanmugam
- Erik Södersten
- Jacqueline Prieto
- Linda Strömqvist Meuzelaar
- Purvesh Khatri
- Romain Wyss
- Samuel G Schumacher
- Sara Banderby
- Stefano Ongarello
Organizations
- Department of Foreign Affairs and Trade
- Dr. Ralph and Marian Falk Medical Research Trust
- Federal Ministry of Research, Technology and Space
- Gates Foundation
- Ministry of Foreign Affairs of the Netherlands
- National Institutes of Health
- Stanford University
- United States Department of Defense
- University Hospital Heidelberg