A New Gorilla Adenoviral Vector with Natural Lung Tropism Avoids Liver Toxicity and Is Amenable to Capsid Engineering and Vector Retargeting
Abstract
In the aggregate, our mouse studies suggest that GAd is a promising gene therapy vector that utilizes lung ECs as a source of therapeutic payload production and a highly desirable toxicity profile. Further genetic engineering of the GAd capsid holds the promise of in vivo vector tropism modification and targeting.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 04, 2020
- Source ID
- 10.1128/jvi.00265-20
Entities
People
- David T. Curiel
- Douglas E. Brough
- Elena A. Kashentseva
- Igor P. Dmitriev
- Jie Li
- Zhi Hong Lu
Organizations
- Precigen, Inc
- Washington University School of Medicine