Prior Heterologous Flavivirus Exposure Results in Reduced Pathogenesis in a Mouse Model of Zika Virus Infection
Abstract
The emergence and reemergence of various vector-borne diseases in recent years highlights the need to understand the mechanisms of protection for each pathogen. In this study, we investigated the impact of prior exposure to Zika virus, dengue virus serotypes 2 or 3, or the vaccine strain of yellow fever on pathogenesis and disease outcomes in a mouse model of Zika virus infection.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 26, 2021
- Source ID
- 10.1128/jvi.00573-21
Entities
People
- Abigail K. Coleman
- Amelia K Pinto
- Enbal Shacham
- James D Brien
- Mariah Hassert
- Stephen Scroggins
- Tara L. Steffen
Organizations
- National Institute of Allergy and Infectious Diseases
- Saint Louis University
- United States Department of Defense