A Naturally Occurring Polymorphism in the Base of Sudan Virus Glycoprotein Decreases Glycoprotein Stability in a Species-Dependent Manner
Abstract
Filovirus outbreaks are associated with significant morbidity and mortality. Understanding the structural constraints of filoviral GPs that control virus entry into cells is critical for rational development of novel antivirals to block infection.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 25, 2021
- Source ID
- 10.1128/jvi.01073-21
Entities
People
- Ashley L. Cooney
- Grace A. Schaack
- Jacob Dillard
- Natalie Ruggio
- Nicholas J Lennemann
- Robert A Davey
- Wendy Maury
Organizations
- Boston University
- National Institutes of Health
- United States Department of Defense
- University of Iowa