Distinct Roles of Type I and Type III Interferons during a Native Murine β Coronavirus Lung Infection
Abstract
The antiviral and pathological potential of type I and type III interferons during coronavirus infection remains poorly defined, and opposite findings have been reported. We report that both type I and type III interferons have anticoronaviral activities, but their potency and organ specificity differ.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 26, 2022
- Source ID
- 10.1128/jvi.01241-21
Entities
People
- Andrew Wang
- Anush Swaminathan
- Brandon K. Hilliard
- Charles S Dela Cruz
- Craig B Wilen
- Cuiling Zhang
- Gayatri Gupta
- Hua Qing
- Hyeon-jun Shin
- Jooyoung Kim
- Justin Tian
- Kavita Israni-winger
- Lawrence H. Young
- Lin Wang
- Lokesh Sharma
- Min-Jong Kang
- Sang-hun Kim
- Sergei Kotenko
- Shuta Ishibe
- Susan R Compton
- Victoria Habet
- Xiaohua Peng
- Xuefei Tian
- Yina Ma
Organizations
- American Lung Association
- Chongqing Medical University
- Francis Family Foundation
- National Institutes of Health
- Rutgers University
- The Pew Charitable Trusts
- United States Department of Defense
- United States Department of Veterans Affairs
- Veterans Health Administration
- Yale School of Medicine