SARS-CoV-2 Causes Lung Infection without Severe Disease in Human ACE2 Knock-In Mice
Abstract
Mouse models of SARS-CoV-2 pathogenesis have facilitated the rapid evaluation of countermeasures. While the first generation of models developed pneumonia and severe disease after SARS-CoV-2 infection, they relied on ectopic expression of supraphysiological levels of human ACE2 (hACE2).
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 12, 2022
- Source ID
- 10.1128/jvi.01511-21
Entities
People
- Adolfo García-Sastre
- Emma S. Winkler
- Fahmida Alam
- James Brett Case
- Melissa B. Uccellini
- Michael J Holtzman
- Michael S. Diamond
- Michael Schotsaert
- Rita E. Chen
- Soner Yildiz
Organizations
- Icahn School of Medicine at Mount Sinai
- National Institutes of Health
- Washington University School of Medicine
- Washington University in St. Louis