Antibody-Mediated Protective Mechanisms Induced by a Trivalent Parainfluenza Virus-Vectored Ebolavirus Vaccine
Abstract
The symptoms of the disease caused by the ebolaviruses Ebola, Bundibugyo, and Sudan are similar, and their areas of endemicity overlap. However, because of the limited antigenic relatedness of the ebolavirus glycoprotein (GP) used in all candidate vaccines against these viruses, they protect only against homologous and not against heterologous ebolaviruses. Therefore, a broadly specific pan-ebolavirus vaccine is required, and this might be achieved by administration of a cocktail of vaccines. The effects of cocktail administration of ebolavirus vaccines on the antibody repertoire remain unknown. Here, an in-depth analysis of the antibody responses to administration of a cocktail of human parainfluenza virus type 3-vectored vaccines against individual ebolaviruses was performed, which included analysis of binding to GP, neutralization of individual ebolaviruses, epitope specificity, Fc-mediated functions, and protection against the three ebolaviruses. The results demonstrated potent and balanced responses against individual ebolaviruses and no significant reduction of the responses compared to that induced by individual vaccines.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 15, 2019
- Source ID
- 10.1128/jvi.01845-18
Entities
People
- Alexander Bukreyev
- Bronwyn M Gunn
- Delphine C. Malherbe
- Galit Alter
- J. Brian Kimble
- James E. Crowe, Jr.
- Kai Huang
- Khaled S. Mohamed
- Marcus M. Karim
- Mathieu Iampietro
- Michelle Meyer
- Pavlo Gilchuk
- Philipp A. Ilinykh
- Surendra Negi
- Werner Braun
- Yuri I. Wolf
Organizations
- Defense Threat Reduction Agency
- Galveston National Laboratory
- Harvard University
- National Institute of Allergy and Infectious Diseases
- United States National Library of Medicine
- University of Texas Medical Branch
- Vanderbilt University