Hibernation-Promoting Factor Sequesters Staphylococcus aureus Ribosomes to Antagonize RNase R-Mediated Nucleolytic Degradation

Abstract

Ribosome hibernation is pivotal for the rapid recovery of translation after quiescence in both bacteria and eukaryotes. Ribosome hibernation factors sterically occlude the entry of mRNA and tRNA and are thought to primarily maintain ribosomes in a translation-repressive state, thereby providing a pool of readily recyclable 70S or 80S complexes upon dissociation of the hibernation factors.

Document Details

Document Type
Pub Defense Publication
Publication Date
Aug 31, 2021
Source ID
10.1128/mbio.00334-21

Entities

People

  • Anna LipoĊ„ska
  • Mee-Ngan F Yap

Organizations

  • National Institutes of Health
  • Northwestern University
  • United States Department of Defense

Tags

Fields of Study

  • Biology

Readers

  • Cardiovascular Physiology
  • Microbial Pathology
  • Molecular Genetics