Burkholderia ubonensis Meropenem Resistance: Insights into Distinct Properties of Class A β-Lactamases in Burkholderia cepacia Complex and Burkholderia pseudomallei Complex Bacteria
Abstract
Burkholderia pseudomallei causes melioidosis, a tropical disease that is highly fatal if not properly treated. Our data show that, in contrast to B. pseudomallei , B. ubonensis β-lactam resistance is fundamentally different because intrinsic resistance is mediated by an inducible class A β-lactamase. This includes resistance to carbapenems. Our work demonstrates that studies with near-neighbor species are informative about the diversity of antimicrobial resistance in Burkholderia and can also provide clues about the potential of resistance transfer between bacteria inhabiting the same environment. Knowledge about potential adverse challenges resulting from the horizontal transfer of resistance genes between members of the two complexes enables the design of effective countermeasures.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 28, 2020
- Source ID
- 10.1128/mbio.00592-20
Entities
People
- Bart J. Currie
- Carina M. Hall
- David M Wagner
- Herbert P Schweizer
- Jason W. Sahl
- Jessica R Webb
- Nawarat Somprasong
- Paul Keim
Organizations
- Charles Darwin University
- Defense Threat Reduction Agency
- National Institutes of Health
- Northern Arizona University
- Royal Darwin Hospital
- University of Florida