CD4 + T Cell-Mimicking Nanoparticles Broadly Neutralize HIV-1 and Suppress Viral Replication through Autophagy
Abstract
HIV-1 is a major global health challenge. The development of an effective vaccine and/or a therapeutic cure is a top priority. The creation of vaccines that focus an antibody response toward a particular epitope of a protein has shown promise, but the genetic diversity of HIV-1 hinders this progress. Here we developed an approach using nanoengineered CD4 + T cell membrane-coated nanoparticles (TNP). Not only do TNP effectively neutralize all strains of HIV-1, but they also selectively bind to infected cells and decrease the release of HIV-1 particles through an autophagy-dependent mechanism with no drug-induced off-target or cytotoxic effects on bystander cells.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 27, 2020
- Source ID
- 10.1128/mbio.00903-20
Entities
People
- Erin Maule
- Gang Zhang
- Grant R. Campbell
- Jonathan Hanna
- Liangfang Zhang
- Qiangzhe Zhang
- Stephen A Spector
- Weiwei Gao
Organizations
- Defense Threat Reduction Agency
- National Institute of Neurological Disorders and Stroke
- Rady Children's Hospital
- University of California, San Diego