Defining the Benefits of Antibiotic Resistance in Commensals and the Scope for Resistance Optimization
Abstract
Antibiotic resistance is commonly viewed as universally costly, regardless of which bacterial cells express resistance. Here, we derive an opposing logic, where resistance in commensal bacteria can lead to reductions in pathogen density and improved outcomes on both the patient and public health scales.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 28, 2023
- Source ID
- 10.1128/mbio.01349-22
Entities
People
- Kristofer Wollein Waldetoft
- Rachel Kuske
- Sam P Brown
- Sarah Sundius
Organizations
- Army Research Office
- Centers for Disease Control and Prevention
- Cystic Fibrosis Foundation
- Georgia Tech
- National Institutes of Health
- Sahlgrenska University Hospital