Corynebacterium pseudodiphtheriticum Exploits Staphylococcus aureus Virulence Components in a Novel Polymicrobial Defense Strategy
Abstract
While some individuals are nasally colonized with S. aureus , the underlying factors that determine colonization are not understood. There is increasing evidence that indicates that resident bacteria play a role; some commensal species can eradicate S. aureus from the nasal cavity. Among these, Corynebacterium pseudodiphtheriticum can eliminate S. aureus from the human nose. We sought to understand this phenomenon at a molecular level and found that C. pseudodiphtheriticum produces a factor(s) that specifically kills S. aureus . While resistant S. aureus isolates were recovered at a low frequency, resistance came at the cost of attenuated virulence in these strains. Molecular dissection of the specific strategies used by C. pseudodiphtheriticum to kill S. aureus could lead to the development of novel treatments or therapies. Furthermore, commensal competition that requires virulence components of the competitor may represent an exciting and unexplored possibility for development of novel antimicrobial compounds.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 26, 2019
- Source ID
- 10.1128/mbio.02491-18
Entities
People
- Britney L. Hardy
- D Scott Merrell
- Daniel P. Riggins
- Michael Otto
- Roger D. Plaut
- Scott Stibitz
- Seth W. Dickey
Organizations
- Food and Drug Administration
- National Institute of Allergy and Infectious Diseases
- Uniformed Services University of the Health Sciences
- United States Department of Defense