Large-Scale CRISPRi and Transcriptomics of Staphylococcus epidermidis Identify Genetic Factors Implicated in Lifestyle Versatility
Abstract
Staphylococcus epidermidis is a bacteria that broadly inhabits healthy human skin, yet it is also a common cause of skin infections and bloodstream infections associated with implanted medical devices. Because human skin has many different types of S. epidermidis , each containing different genes, our goal is to determine how these different genes allow S. epidermidis to switch from healthy growth in the skin to being an infectious pathogen.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 20, 2022
- Source ID
- 10.1128/mbio.02632-22
Entities
People
- Changhui Guan
- Dean Kim
- Elizabeth Fleming
- Johanna P. Riera Puma
- Julia Oh
- Michelle Spoto
- Yvette Ondouah Nzutchi
Organizations
- Jackson Laboratory
- National Institutes of Health
- National Science Foundation
- United States Department of Defense
- University of Connecticut Health Center