Molecular Architecture of Early Dissemination and Massive Second Wave of the SARS-CoV-2 Virus in a Major Metropolitan Area
Abstract
There is concern about second and subsequent waves of COVID-19 caused by the SARS-CoV-2 coronavirus occurring in communities globally that had an initial disease wave. Metropolitan Houston, TX, with a population of 7 million, is experiencing a massive second disease wave that began in late May 2020. To understand SARS-CoV-2 molecular population genomic architecture and evolution and the relationship between virus genotypes and patient features, we sequenced the genomes of 5,085 SARS-CoV-2 strains from these two waves. Our report provides the first molecular characterization of SARS-CoV-2 strains causing two distinct COVID-19 disease waves.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 22, 2020
- Source ID
- 10.1128/mbio.02707-20
Entities
People
- Chia-Wei Chou
- Daniel R. Boutz
- David W. Bernard
- Ghazaleh Eskandari
- Heather Hendrickson
- Hoang A. T. Nguyen
- Hung-che Kuo
- Ilya J Finkelstein
- J. Hunter Long
- James J. Davis
- James M. Musser
- Jason S. McLellan
- Jimmy Gollihar
- Jule Goike
- Kamyab Javanmardi
- Layne Pruitt
- Marcus Nguyen
- Matthew Ojeda Saavedra
- Maulik Shukla
- Muthiah Kumaraswami
- Paul A. Christensen
- Prasanti Yerramilli
- Randall J. Olsen
- S Wesley Long
- Sishir Subedi
Organizations
- Argonne National Laboratory
- Cancer Prevention and Research Institute of Texas
- National Institute of Allergy and Infectious Diseases
- National Institutes of Health
- National Science Foundation
- Robert A. Welch Foundation
- University of Chicago
- University of Texas at Austin
- Weill Cornell Medicine