Influenza A Virus Defective Viral Genomes Are Inefficiently Packaged into Virions Relative to Wild-Type Genomic RNAs
Abstract
Defective interfering particles (DIPs) are commonly produced by RNA viruses and have been implicated in modulating clinical infection outcomes; hence, there is increasing interest in the potential of DIPs as antiviral therapeutics. For influenza viruses, DIPs are formed by the packaging of genomic RNAs harboring internal deletions.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 21, 2021
- Source ID
- 10.1128/mbio.02959-21
Entities
People
- Aartjan J W te Velthuis
- Christopher B Brooke
- Fadi G Alnaji
- Joel Rivera-cardona
- William K. Reiser
Organizations
- National Institute of Allergy and Infectious Diseases
- Princeton University
- University of Illinois Urbana–Champaign
- Wellcome Trust