Defective Interfering Viral Particle Treatment Reduces Clinical Signs and Protects Hamsters from Lethal Nipah Virus Disease
Abstract
Here, we demonstrate that treatment with defective interfering particles (DIs), a natural by-product of viral infection, can significantly improve the clinical course and outcome of viral disease. When present with their parental virus, DIs can directly or indirectly alter viral propagation kinetics and exert potent inhibitory properties in cell culture.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 26, 2022
- Source ID
- 10.1128/mbio.03294-21
Entities
People
- Christina F Spiropoulou
- Florine Scholte
- Jessica R Harmon
- Jessica R. Spengler
- Joann D. Coleman-mccray
- Joel M. Montgomery
- Michael K. Lo
- Sarah C. Genzer
- Stephen R Welch
- Stuart T. Nichol
Organizations
- Centers for Disease Control and Prevention