Small-Molecule Mn Antioxidants in Caenorhabditis elegans and Deinococcus radiodurans Supplant MnSOD Enzymes during Aging and Irradiation
Abstract
The current theory of cellular defense against oxidative damage identifies antioxidant enzymes as primary defenders against ROS, with MnSOD being the preeminent superoxide (O 2 •− ) scavenger. However, MnSOD is shown to be dispensable both for radiation resistance and longevity in model organisms, the bacterium Deinococcus radiodurans and the nematode Caenorhabditis elegans .
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 22, 2022
- Source ID
- 10.1128/mbio.03394-21
Entities
People
- Ajay Sharma
- Belinda Jackson-thompson
- Brian M. Hoffman
- Cene Gostinčar
- Chandra Srinivasan
- Elena K. Gaidamakova
- Igor Shuryak
- Irina Balygina
- Isabel H. Conze
- Kira S. Makarova
- Michael J. Daly
- Olga Grichenko
- Polina Klimenkova
- Robert P. Volpe
- Rok Tkavc
- Vera Y. Matrosova
- William H. Horne
- Xiao Chen
Organizations
- California State University
- Columbia University
- Defense Threat Reduction Agency
- Henry M. Jackson Foundation for the Advancement of Military Medicine
- Northwestern University
- Novosibirsk State University
- Slovenian Research and Innovation Agency
- Uniformed Services University of the Health Sciences
- United States National Library of Medicine
- University of Cologne
- University of Ljubljana
- Yusuf Hamied Department of Chemistry