Peptidyl tRNA Hydrolase Is Required for Robust Prolyl-tRNA Turnover in Mycobacterium tuberculosis
Abstract
Peptidyl tRNA hydrolase (Pth) is an enzyme that cuts unfinished peptides off tRNA that has been prematurely released from a stalled ribosome. Pth is essential in nearly all bacteria, including the pathogen Mycobacterium tuberculosis (Mtb), but it has not been clear why.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 28, 2023
- Source ID
- 10.1128/mbio.03469-22
Entities
People
- Eric Rubin
- Francesca G. Tomasi
- Jessica T. P. Schweber
- Junhao Zhu
- Laura A. T. Cleghorn
- Matthew K. Waldor
- Satoshi Kimura
- Simon R. Green
- Susan H. Davis
Organizations
- Brigham and Women's Hospital
- Harvard Medical School
- Harvard University
- Howard Hughes Medical Institute
- National Institute of Allergy and Infectious Diseases
- United States Department of Defense
- University of Dundee