Low-Dose Exposure to Ganglioside-Mimicking Bacteria Tolerizes Human Macrophages to Guillain-Barré Syndrome-Associated Antigens
Abstract
In this study, we demonstrated that it is possible to tolerize immune cells to potentially dampen the autoreactive proinflammatory immune response against Guillain-Barré syndrome (GBS)-associated antigens. The innate immune response functions to arm the host against bacterial attack, but it can be tricked into recognizing the host’s own cells when infectious bacteria display sugar structures that mimic human glycans.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 22, 2022
- Source ID
- 10.1128/mbio.03852-21
Entities
People
- Christine M. Szymanski
- Frederick D. Quinn
- Lauren Essler
- Robert T. Patry
- Silke Andresen
Organizations
- United States Department of Defense
- University of Georgia