The Francisella tularensis Polysaccharides: What Is the Real Capsule?
Abstract
Francisella tularensisis a tier 1 select agent responsible for tularemia in humans and a wide variety of animal species. Extensive research into understanding the virulence factors of the bacterium has been ongoing to develop an efficacious vaccine. At least two such virulence factors are described as capsules ofF. tularensis: the O-antigen capsule and the capsule-like complex (CLC). These two separate entities aid in avoiding host immune defenses but have not been clearly differentiated.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 19, 2020
- Source ID
- 10.1128/mmbr.00065-19
Entities
People
- Kelly C. Freudenberger Catanzaro
- Thomas J. Inzana
Organizations
- Long Island University
- National Institute of Allergy and Infectious Diseases
- United States Department of Defense
- Virginia Tech
- Virginia–Maryland Regional College of Veterinary Medicine