High-Throughput Sequence Analysis of Peripheral T-Cell Lymphomas Indicates Subtype-Specific Viral Gene Expression Patterns and Immune Cell Microenvironments
Abstract
In this study, we utilized next-generation sequencing data from 7 different studies of peripheral T-cell lymphoma (PTCL) patient samples to globally assess viral associations, provide insights into the contributions of EBV gene expression to the tumor phenotype, and assess the unique roles of EBV in modulating the immune cell tumor microenvironment. These studies revealed potential roles for EBV replication genes in some PTCL subtypes, the possible role of additional human tumor viruses in rare cases of PTCLs, and a role for EBV in providing a unique immune microenvironmental niche in one subtype of PTCLs. Together, these studies provide new insights into the understudied role of tumor viruses in PTCLs.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 28, 2019
- Source ID
- 10.1128/msphere.00248-19
Entities
People
- Claire Roberts
- Erik K Flemington
- Hani Nakhoul
- Xia Wang
- Yan Dong
- Zhen Lin
Organizations
- National Institutes of Health
- Tulane University of Louisiana
- United States Department of Defense