Establishment of a Controlled Human Infection Model with a Lyophilized Strain of Shigella sonnei 53G
Abstract
Controlled human infection models (CHIMs) are invaluable tools utilized to understand the human response to infection, potentially leading to protective immune mechanisms and allowing efficacy testing of enteric countermeasures, including vaccines, antibiotics, and other products. The development of an improved Shigella CHIM for both Shigella sonnei and Shigella flexneri is consistent with international efforts, supported by international donors and the World Health Organization, focused on standardizing Shigella CHIMs and using them to accelerate Shigella vaccine development. The use of lyophilized Shigella challenge strains rather than plate-grown inoculum preparations is considered an important step forward in the standardization process. Furthermore, the results of studies such as this justify the development of lyophilized preparations for additional epidemiologically important S. flexneri serotypes, including S. flexneri 3a and S. flexneri 6.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 28, 2020
- Source ID
- 10.1128/msphere.00416-20
Entities
People
- Akamol E. Suvarnapunya
- Alan Fix
- Amanda Lynen
- Amy Hoeper
- Chad K Porter
- Kristen A. Clarkson
- Lakshmi Chandrasekaran
- Malabi M. Venkatesan
- Michelle Dickey
- Monica Mcneal
- Nicole Maier
- Robert W Frenck
- Robert W Kaminski
- Sachin Mani
- Susan Parker
Organizations
- Cincinnati Children's Hospital Medical Center
- Naval Medical Research Center
- PATH
- United States Department of Defense
- University of Cincinnati
- Walter Reed Army Institute of Research