Sustained Replication of Synthetic Canine Distemper Virus Defective Genomes In Vitro and In Vivo
Abstract
Defective interfering (DI) genomes have long been considered inconvenient artifacts that suppressed viral replication in vitro . However, advances in sequencing technologies have led to DI genomes being identified in clinical samples, implicating them in disease progression and outcome.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 27, 2021
- Source ID
- 10.1128/msphere.00537-21
Entities
People
- Christina F Spiropoulou
- David E. Wentworth
- Gregory W. Ho
- Linda J. Rennick
- Natasha L Tilston
- Reed Shabman
- Rik L. de Swart
- Rory D. de Vries
- Sham Nambulli
- Stephen R Welch
- Stuart T. Nichol
- W Paul Duprex
Organizations
- Boston University
- Centers for Disease Control and Prevention
- Erasmus MC
- J. Craig Venter Institute
- University of Pittsburgh
- University of Pittsburgh School of Medicine