Rousette Bat Dendritic Cells Overcome Marburg Virus-Mediated Antiviral Responses by Upregulation of Interferon-Related Genes While Downregulating Proinflammatory Disease Mediators
Abstract
Marburg viruses (MARVs) cause severe human disease resulting from aberrant immune responses. Dendritic cells (DCs) are primary targets of infection and are dysregulated by MARV. Dysregulation of DCs facilitates MARV replication and virus dissemination and influences downstream immune responses that result in immunopathology. Egyptian rousette bats (ERBs) are natural reservoirs of MARV, and infection results in virus replication and shedding, with asymptomatic control of the virus within weeks. The mechanisms that bats employ to appropriately respond to infection while avoiding disease are unknown. Because DC infection and modulation are important early events in human disease, we measured the transcriptional responses of ERB DCs to MARV. The significance of this work is in identifying cell type-specific coevolved responses between ERBs and MARV, which gives insight into how bat reservoirs are able to harbor MARV and permit viral replication, allowing transmission and maintenance in the population while simultaneously preventing immunopathogenesis.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 18, 2019
- Source ID
- 10.1128/msphere.00728-19
Entities
People
- Amy J Schuh
- Brian R Amman
- Catherine E Arnold
- Cesar G. Albariño
- Gustavo F. Palacios
- Jessica R. Spengler
- Jonathan C. Guito
- Jonathan S Towner
- Joseph Prescott
- Lisa W. Guerrero
- Mariano Sanchez-Lockhart
- Tara K. Sealy
Organizations
- Centers for Disease Control and Prevention
- Defense Threat Reduction Agency
- Robert Koch Institute
- United States Army Medical Research Institute of Infectious Diseases
- University of Nebraska Medical Center