Immunization of Rabbits with a QuadrivalentShigellaBioconjugate Vaccine Induces Functional Antibodies Reactive withShigellaIsolates from Kenya
Abstract
Diarrheal diseases are the third leading cause of death globally, disproportionally affecting low- to middle-income countries like Kenya, withShigellaspecies being the leading cause of bacterial diarrhea, especially in children. The low infectious dose and high antibiotic resistance levels complicate treatment, leading to long-term sequelae that necessitate control measures such as vaccines to reduce morbidity and mortality rates, especially among children under 5 years of age.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 29, 2022
- Source ID
- 10.1128/msphere.01020-21
Entities
People
- Anita M. Dreyer
- Elizabeth A. Odundo
- Hailey P. Weerts
- Joerg Schneider
- Lilian Ogonda
- Lillian Musila
- Paula Carranza
- Robert W Kaminski
Organizations
- Maseno University
- United States Department of Defense
- Walter Reed Army Institute of Research