Fluoride Depletes Acidogenic Taxa in Oral but Not Gut Microbial Communities in Mice
Abstract
Fluoride has been added to drinking water and dental products since the 1950s. The beneficial effects of fluoride on oral health are due to its ability to inhibit the growth of bacteria that cause dental caries. Despite widespread human consumption of fluoride, there have been only two studies of humans that considered the effect of fluoride on human-associated microbial communities, which are increasingly understood to play important roles in health and disease. Notably, neither of these studies included a true cross-sectional control lacking fluoride exposure, as study subjects continued baseline fluoride treatment in their daily dental hygiene routines. To our knowledge, this work (in mice) is the first controlled study to assess the independent effects of fluoride exposure on the oral and gut microbial communities. Investigating how fluoride interacts with host-associated microbial communities in this controlled setting represents an effort toward understanding how common environmental exposures may potentially influence health.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 29, 2017
- Source ID
- 10.1128/msystems.00047-17
Entities
People
- Andy Shi
- Carey A. Gallini
- Casey R. Dulong
- Curtis Huttenhower
- Emma Schwager
- Eric A. Franzosa
- Galeb S. Abu-ali
- Koji Yasuda
- Lauren J. Mclver
- Randall N. Schwager
- Tiffany Hsu
- Wendy S. Garrett
- Xochitl C. Morgan
Organizations
- Army Research Office
- Broad Institute
- Dana–Farber Cancer Institute
- Harvard University
- National Science Foundation
- Office of the Director
- University of Otago