Resources to Facilitate Use of the Altered Schaedler Flora (ASF) Mouse Model to Study Microbiome Function
Abstract
Improved experimental systems are needed to advance our understanding of how the gut microbiome influences processes of the mammalian host as well as microbial community structure and function. An approach that is receiving considerable attention is the use of animal models that harbor a stable microbiota of known composition, i.e., defined microbiota, which enables control over an otherwise highly complex and variable feature of mammalian biology.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 26, 2022
- Source ID
- 10.1128/msystems.00293-22
Entities
People
- Aleksandar D. Kostic
- Alexandra Proctor
- Gregory J. Phillips
- Joseph F. Pierre
- Michael J. Wannemuehler
- Peter D. Karp
- Shadi Parvinroo
- Sonny T M Lee
- Suzanne Paley
- Tanner Richie
- Xinglin Jia
Organizations
- Defense Threat Reduction Agency
- Harvard University
- Iowa State University
- Kansas State University
- National Cancer Institute
- National Institute of General Medical Sciences
- SRI International
- University of Wisconsin–Madison