Yersinia pseudotuberculosisYopJ Limits Macrophage Response by Downregulating COX-2-Mediated Biosynthesis of PGE2 in a MAPK/ERK-Dependent Manner
Abstract
PGE2 is a critical immunomodulatory lipid, but its role in bacterial infection and pathogen clearance is poorly understood. We previously demonstrated that PGE2 leads to macrophage polarization toward the M1 phenotype and stimulates inflammasome activation in infected macrophages.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 03, 2021
- Source ID
- 10.1128/spectrum.00496-21
Entities
People
- Austin E. F. Sheppe
- Daniel M. Czyz
- John Santelices
- Mariola J. Ferraro
Organizations
- National Institute of Allergy and Infectious Diseases
- United States Department of Defense
- University of Florida