Single-Cell Profiling of Latently SIV-Infected CD4 + T Cells Directly Ex Vivo to Reveal Host Factors Supporting Reservoir Persistence
Abstract
Effective combination antiretroviral therapy controls HIV-1 infection but fails to eliminate latent viral reservoirs that give rise to viremia upon treatment interruption. Strategies to eradicate latently infected cells require a better understanding of their biology and distinguishing features to promote their elimination.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 29, 2022
- Source ID
- 10.1128/spectrum.00604-22
Entities
People
- Andrey Tokarev
- Diane L Bolton
- Dohoon Kim
- Kawthar Machmach
- Matthew Creegan
- Michael A Eller
Organizations
- Henry M. Jackson Foundation for the Advancement of Military Medicine
- United States Department of Defense
- Walter Reed Army Institute of Research