Disruption of NBS1/MRN Complex Formation by E4orf3 Supports NF-κB That Licenses E1B55K-Deleted Adenovirus-Infected Cells to Accumulate DNA>4n
Abstract
Genome instability, a hallmark of cancer, exists as part of a cycle that leads to DNA damage and DNA > 4n that further enhances genome instability. Ad E4orf3 is a viral oncogene. Here, we describe E4orf3 mediated signaling events that support DNA > 4n in Δ E1B Ad-infected cells. These signaling events may be linked to the oncogenic potential of E4orf3 and may provide a basis for how some cells survive with DNA > 4n.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 23, 2022
- Source ID
- 10.1128/spectrum.01881-21
Entities
People
- Madison Moore
- Marjorie Robert-Guroff
- Michael A Thomas
- Nujud Almuzaini
Organizations
- Howard University
- National Cancer Institute
- National Institute of Allergy and Infectious Diseases