PNPase and RhlB Interact and Reduce the Cellular Availability of Oxidized RNA in Deinococcus radiodurans
Abstract
Oxidative RNA damage can be caused by oxidative stress, such as hydrogen peroxide, ionizing radiation, and antibiotic treatment. 8-oxo-7,8-dihydroguanine (8-oxoG), a major type of oxidized RNA, is highly mutagenic and participates in a variety of disease occurrences and development. Although several proteins have been identified to recognize 8-oxoG-modified RNA, the knowledge of how RNA oxidative damage is controlled largely remains unclear, especially in nonmodel organisms.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 31, 2022
- Source ID
- 10.1128/spectrum.02140-22
Entities
People
- Jaden Fang
- Jessie Jiang
- Lydia M Contreras
- Runhua Han
Organizations
- Air Force Research Laboratory Information Directorate
- Defense Threat Reduction Agency
- National Institutes of Health
- University of Texas at Austin