Impact of broad regulatory regions on Gdf5 expression and function in knee development and susceptibility to osteoarthritis
Abstract
Given the role of growth and differentiation factor 5 (GDF5) in knee development and osteoarthritis risk, we sought to characterise knee defects resulting fromGdf5loss of function and how its regulatory regions control knee formation and morphology.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 08, 2018
- Source ID
- 10.1136/annrheumdis-2017-212475
Entities
People
- Ata M Kiapour
- Hao Chen
- Jiaxue Cao
- Mariel Young
- Michael Schoor
- Steven K Pregizer
- Terence D Capellini
- Vicki Rosen
- Zun Liu
Organizations
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- National Institutes of Health
- United States Department of Defense