PTPN14 phosphatase and YAP promote TGFβ signalling in rheumatoid synoviocytes
Abstract
We aimed to understand the role of the tyrosine phosphatase PTPN14—which in cancer cells modulates the Hippo pathway by retaining YAP in the cytosol—in fibroblast-like synoviocytes (FLS) from patients with rheumatoid arthritis (RA).
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 26, 2019
- Source ID
- 10.1136/annrheumdis-2018-213799
Entities
People
- Ana Lonic
- Angel Bottini
- Beatrix Bartok
- Costantino Pitzalis
- Cristiano Sacchetti
- David L Boyle
- Deepa Hammaker
- Dennis J. Wu
- Gary S Firestein
- Karen M. Doody
- Lin Liu
- Maripat Corr
- Martina Zoccheddu
- Michele Bombardieri
- Michelle Le Roux
- Myles Lewis
- Nunzio Bottini
- Rizi Ai
- Stephanie M. Stanford
- Tzu-ching Meng
- Vida Zhang
- Wei Wang
- Xiaochun Li
- Yeesim Khew-goodall
Organizations
- National Institute of Allergy and Infectious Diseases
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- United States Department of Defense