Fexofenadine inhibits TNF signaling through targeting to cytosolic phospholipase A2 and is therapeutic against inflammatory arthritis
Abstract
Tumour necrosis factor alpha (TNF-α) signalling plays a central role in the pathogenesis of various autoimmune diseases, particularly inflammatory arthritis. This study aimed to repurpose clinically approved drugs as potential inhibitors of TNF-α signalling in treatment of inflammatory arthritis.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 13, 2019
- Source ID
- 10.1136/annrheumdis-2019-215543
Entities
People
- Aubryanna Hettinghouse
- Chao Wang
- Chen Zhang
- Chuanju Liu
- Guozhi Xiao
- Jody Liu
- Ronghan Liu
- Shuya Wang
- Wenyu Fu
- Xiangli Zhao
- Yazhou Cui
- Yuehong Chen
- Yufei Bi
- Zhe-sheng Chen
- Zi-ning Lei
Organizations
- Office of the Director
- United States Department of Defense