14-3-3 epsilon is an intracellular component of TNFR2 receptor complex and its activation protects against osteoarthritis
Abstract
Osteoarthritis (OA) is the most common joint disease; however, the indeterminate nature of mechanisms by which OA develops has restrained advancement of therapeutic targets. TNF signalling has been implicated in the pathogenesis of OA. TNFR1 primarily mediates inflammation, whereas emerging evidences demonstrate that TNFR2 plays an anti-inflammatory and protective role in several diseases and conditions. This study aims to decipher TNFR2 signalling in chondrocytes and OA.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 05, 2021
- Source ID
- 10.1136/annrheumdis-2021-220000
Entities
People
- Aubryanna Hettinghouse
- Chuanju Liu
- Eric Strauss
- Jonathan Samuels
- Jyoti Mundra
- Meng Chen
- Mukundan Attur
- Philipp Leucht
- Ran Schwarzkopf
- Ronghan Liu
- Wenhao Song
- Wenhuo Hu
- Wenyu Fu
- Xiang Ding
- Young-su Yi
- Yuanjing Ding
- Yujianan Chen
Organizations
- Foundation for the National Institutes of Health
- United States Department of Defense