Digoxin targets low density lipoprotein receptor-related protein 4 and protects against osteoarthritis
Abstract
Dysregulated chondrocyte metabolism is closely associated with the pathogenesis of osteoarthritis (OA). Suppressing chondrocyte catabolism to restore cartilage homeostasis has been extensively explored, whereas far less effort has been invested toward enhancing chondrocyte anabolism. This study aimed to repurpose clinically approved drugs as potential stimulators of chondrocyte anabolism in treating OA.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 01, 2021
- Source ID
- 10.1136/annrheumdis-2021-221380
Entities
People
- Asya Khleborodova
- Aubryanna Hettinghouse
- Chao Zeng
- Chuanju Liu
- Guanghua Lei
- Jing Wu
- Kaidi Wang
- Nan Jiang
- Xian-yi Cai
- Xiang Ding
- Zhe-sheng Chen
- Zi-ning Lei
Organizations
- Foundation for the National Institutes of Health
- United States Department of Defense