OA susceptibility in mice is partially mediated by the gut microbiome, is transferrable via microbiome transplantation and is associated with immunophenotype changes
Abstract
The Murphy Roths Large (MRL)/MpJ ‘superhealer’ mouse strain is protected from post-traumatic osteoarthritis (OA), although no studies have evaluated the microbiome in the context of this protection. This study characterised microbiome differences between MRL and wild-type mice, evaluated microbiome transplantation and OA and investigated microbiome-associated immunophenotypes.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 18, 2023
- Source ID
- 10.1136/ard-2023-224907
Entities
People
- Aleksander Szymczak
- Cassandra Velasco
- Christopher M. Dunn
- Emmaline Prinz
- G. Dyson
- Leoni Schlupp
- Matlock Jeffries
- Montana Barrett
- Vladislav Izda
Organizations
- Congressionally Directed Medical Research Programs
- National Institutes of Health