Physical activity, sedentary time and breast cancer risk: a Mendelian randomisation study
Abstract
Physical inactivity and sedentary behaviour are associated with higher breast cancer risk in observational studies, but ascribing causality is difficult. Mendelian randomisation (MR) assesses causality by simulating randomised trial groups using genotype. We assessed whether lifelong physical activity or sedentary time, assessed using genotype, may be causally associated with breast cancer risk overall, pre/post-menopause, and by case-groups defined by tumour characteristics.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 06, 2022
- Source ID
- 10.1136/bjsports-2021-105132
Entities
People
- A Heather Eliassen
- Abctb Investigators
- Alicja Wolk
- Alison Dunning
- Allison W. Kurian
- Alpa Patel
- Andrew F. Olshan
- Angela Cox
- Anna Jakubowska
- Anna Marie Mulligan
- Annelie Augustinsson
- Annika Lindblom
- Anthony Howell
- Anthony Swerdlow
- Antoinette Hollestelle
- Argyrios Ziogas
- Arto Mannermaa
- Atocha Romero
- Audrey Jung
- Barbara Wappenschmidt
- Bernardo Bonanni
- Brigid M. Lynch
- Brigitte Rack
- Cari M. Kitahara
- Carl Blomqvist
- Celine M. Vachon
- Christine B. Ambrosone
- Christine L. Clarke
- Christoph Engel
- Christopher A. Haiman
- Christopher Scott
- Clarice R. Weinberg
- Dale Sandler
- Dallas R English
- Daniele Campa
- David J. Hunter
- Diana M. Eccles
- Diether Lambrechts
- Dijana Plaseska-karanfilska
- Dimitrios Mavroudis
- Don M Conroy
- Douglas F. Easton
- Drakoulis Yannoukakos
- Emmanouil Saloustros
- Eric Hahnen
- Erika Rees-punia
- Esther M. John
- Federico Canzian
- Fergus J. Couch
- Gad Rennert
- Gareth Evans
- Graham Giles
- Harald Surowy
- Hedy S. Rennert
- Heiko Becher
- Heli Nevanlinna
- Henrik Flyger
- Hermann Brenner
- Hoda Anton-Culver
- Håkan Olsson
- Ines Nevelsteen
- Irene L. Andrulis
- Jack A. Taylor
- Jacques Simard
- James V. Lacey
- Jan Lubinski
- Jennifer S Stone
- Jenny Chang-Claude
- Joe Dennis
- John Hopper
- Jose E. Castelao
- José A. García-sáenz
- Julian Peto
- Kamila Czene
- Katerina Kubelka-sabit
- Kenneth Offit
- Kristan J. Aronson
- Kyriaki Michailidou
- Laura E. Beane Freeman
- Lin Fritschi
- Loic Le Marchand
- Lothar Häberle
- Lukas Schwentner
- Maartje J. Hooning
- Manjeet K. Bolla
- Manuela Gago-dominguez
- Marike Gabrielson
- Marina Bermisheva
- Marjanka K Schmidt
- Mark S Goldberg
- Mary B. Daly
- Mary Beth Terry
- María Elena Martínez
- Matthias W. Beckmann
- Mehdi Manoochehri
- Melanie Gündert
- Melissa A. Troester
- Melissa C. Southey
- Melissa H Cessna
- Michael Lush
- Michael Untch
- Michelle Harvie
- Mikael Eriksson
- Miriam Dwek
- Mitul Shah
- Montserrat García-Closas
- Nadege Presneau
- Natalia V. Bogdanova
- Nbcs Collaborators
- Nick Orr
- Niclas Håkansson
- Nicola J Camp
- Olivia Fletcher
- Paolo Radice
- Pascal Guénel
- Paul D P Pharoah
- Per Hall
- Peter A. Fasching
- Peter Devilee
- Peter Hillemanns
- Peter Kraft
- Päivi Auvinen
- Qin Wang
- Rachel A Murphy
- Reiner Hoppe
- Renske Keeman
- Richard M Martin
- Rita K. Schmutzler
- Rob A. E. M. Tollenaar
- Roger L. Milne
- Rudolf Kaaks
- Rulla M. Tamimi
- Sabine Behrens
- Sara Margolin
- Sarah J. Lewis
- Saundra S. Buys
- Sibylle Loibl
- Simon S. Cross
- Stella Koutros
- Stephen Chanock
- Steven N. Hart
- Stig E. Bojesen
- Suzanne C Dixon
- Terry Boyle
- Thilo Dörk
- Thomas Brüning
- Thomas U. Ahearn
- Thérèse Truong
- Usha Menon
- Ute Hamann
- Vessela N. Kristensen
- Vijai Joseph
- Volker Arndt
- Wei Xing Zheng
- William G Newman
- William J. Tapper
- Wolfgang Janni
- Xiao-Ou Shu
Organizations
- AIRC - The Italian Foundation for Cancer Research
- Against Breast Cancer
- Agence Nationale de la Recherche
- Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail
- American Cancer Society
- Breast Cancer Now
- California Department of Public Health
- Canadian Cancer Society Research Institute
- Canadian Institutes of Health Research
- Cancer Council Australia
- Cancer Council Victoria
- Cancer Foundation
- Cancer Institute of New South Wales
- Cancer Research UK
- Centers for Disease Control and Prevention
- Consiglio Nazionale delle Ricerche
- Danish Council for Independent Research | Medical Sciences
- David F. and Margaret T. Grohne Family Foundation
- European Commission
- European Regional Development Fund
- Federal Ministry of Research, Technology and Space
- Fondation de France
- French National Institute of Health and Medical Research
- Friends of the Hannover Medical School
- Genome Canada
- German Cancer Aid
- German Cancer Research Center
- Gunnar Nilsson Cancer Foundation
- Génome Québec
- Hamburger Krebsgesellschaft
- Health and Medical Research Fund
- Hellenic Health Foundation
- Huntsman Cancer Institute
- Institut Gustave Roussy
- Institut National du Cancer
- Institute of Cancer Research
- International Agency for Research on Cancer
- KWF Kankerbestrijding
- Karolinska Institutet
- Kuopio University Hospital
- Macedonian Academy of Sciences and Arts
- Medical Research Council
- Ministry of Health, Social Services and Equality of Spain
- Ministry of Science and Higher Education
- Mrs. Berta Kamprad Foundation
- NIHR Bristol Biomedical Research Centre
- National Breast Cancer Foundation
- National Cancer Institute
- National Health Service
- National Health and Medical Research Council
- National Institute for Health and Care Research
- National Institute of Environmental Health Sciences
- National Institutes of Health
- National League Against Cancer
- Norwegian Cancer Society
- Oak Foundation
- Ovarian Cancer Research Alliance
- Quebec Breast Cancer Foundation
- Research Council of Norway
- Research Foundation - Flanders
- Robert Bosch Stiftung
- Russian Center for Science Information
- Seventh Framework Programme
- Sigrid Jusélius Foundation
- Stavros Niarchos Foundation
- Swedish Cancer Society
- Swedish Research Council
- The Breast Cancer Research Foundation
- United States Department of Defense
- University of Bristol
- University of Crete
- University of Eastern Finland
- University of Helsinki
- University of North Carolina at Chapel Hill
- University of Utah
- Victorian Health Promotion Foundation
- Wellcome
- World Cancer Research Fund UK