Multiplex profiling of peritoneal metastases from gastric adenocarcinoma identified novel targets and molecular subtypes that predict treatment response
Abstract
Peritoneal carcinomatosis (PC) occurs frequently in patients with gastric adenocarcinoma (GAC) and confers a poor prognosis. Multiplex profiling of primary GACs has been insightful but the underpinnings of PC’s development/progression remain largely unknown. We characterised exome/transcriptome/immune landscapes of PC cells from patients with GAC aiming to identify novel therapeutic targets.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 06, 2019
- Source ID
- 10.1136/gutjnl-2018-318070
Entities
People
- Ailing W. Scott
- Brian Badgwell
- Diego A Vicente
- Fatemeh Ghazanfari Amlashi
- George Adrian Calin
- Ghia Tatlonghari
- Guang Peng
- Guangchun Han
- Irene Thomas
- Jaffer A. Ajani
- Jane Rogers
- Jeannelyn Santiano Estrella
- Jian Gu
- Jiangkang Jin
- Jianhua Zhang
- Jody Vykoukal
- Ju-Seog Lee
- Kazuto Harada
- Lang Ma
- Linghua Wang
- Longfei Huo
- Makoto Kobayashi
- Mariela Blum Murphy
- Melissa Pool Pizzi
- Namita Shanbhag
- P. Andrew Futreal
- Randy L Johnson
- Ruiping Wang
- Samir M Hanash
- Shaojun Zhang
- Shumei Song
- Sinchita Roy-chowdhuri
- Wei Zhao
- Xiaochuan Dong
- Xingzhi Song
- Xizeng Mao
- Yan Xu
- Ying Wang
- Zhenning Wang
Organizations
- National Cancer Institute
- United States Department of Defense