Single-cell sequencing unveils distinct immune microenvironments with CCR6-CCL20 crosstalk in human chronic pancreatitis
Abstract
Chronic pancreatitis (CP) is a potentially fatal disease of the exocrine pancreas, with no specific or effective approved therapies. Due to difficulty in accessing pancreas tissues, little is known about local immune responses or pathogenesis in human CP. We sought to characterise pancreatic immune responses using tissues derived from patients with different aetiologies of CP and non-CP organ donors in order to identify key signalling molecules associated with human CP.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 26, 2021
- Source ID
- 10.1136/gutjnl-2021-324546
Entities
People
- Aida Habtezion
- Bomi Lee
- David Heller
- Gregory L. Szot
- Hong Namkoong
- Huang Huang
- Mark M. Davis
- Melena D Bellin
- Sohail Z Husain
- Stephen J Pandol
- Yan Yang
Organizations
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Pancreas Foundation
- United States Department of Defense