Chief cell plasticity is the origin of metaplasia following acute injury in the stomach mucosa
Abstract
Metaplasia arises from differentiated cell types in response to injury and is considered a precursor in many cancers. Heterogeneous cell lineages are present in the reparative metaplastic mucosa with response to injury, including foveolar cells, proliferating cells and spasmolytic polypeptide-expressing metaplasia (SPEM) cells, a key metaplastic cell population. Zymogen-secreting chief cells are long-lived cells in the stomach mucosa and have been considered the origin of SPEM cells; however, a conflicting paradigm has proposed isthmal progenitor cells as an origin for SPEM.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 08, 2021
- Source ID
- 10.1136/gutjnl-2021-325310
Entities
People
- Amy C. Engevik
- Anne R Meyer
- Brianna Caldwell
- Eunyoung Choi
- Jared A. Weis
Organizations
- National Cancer Institute
- National Institute of Diabetes and Digestive and Kidney Diseases
- United States Department of Defense