Blockade of interleukin 10 potentiates antitumour immune function in human colorectal cancer liver metastases
Abstract
Programmed cell death protein 1 (PD-1) checkpoint inhibition and adoptive cellular therapy have had limited success in patients with microsatellite stable colorectal cancer liver metastases (CRLM). We sought to evaluate the effect of interleukin 10 (IL-10) blockade on endogenous T cell and chimeric antigen receptor T (CAR-T) cell antitumour function in CRLM slice cultures.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 15, 2022
- Source ID
- 10.1136/gutjnl-2021-325808
Entities
People
- Arezou Abbasi
- Changting Meng
- Christopher Lausted
- Cynthia Hsu
- Heidi L. Kenerson
- Ian Nicholas Crispe
- James O. Park
- Jason A Carter
- Karan Kohli
- Kevin M. Sullivan
- Kevin P. Labadie
- Marina Chan
- Prajna Guha
- Qiang Tian
- Raymond S Yeung
- Sara K. Daniel
- Steven C Katz
- Taran Gujral
- Teresa S Kim
- Venu G Pillarisetty
- Xiaowei Yan
- Xiuyun Jiang
- Y David Seo
Organizations
- American Cancer Society
- Fibrolamellar Cancer Foundation
- National Cancer Institute
- United States Army