It is better to light a candle than to curse the darkness: single-cell transcriptomics sheds new light on pancreas biology and disease
Abstract
Recent advances in single-cell RNA sequencing and bioinformatics have drastically increased our ability to interrogate the cellular composition of traditionally difficult to study organs, such as the pancreas. With the advent of these technologies and approaches, the field has grown, in just a few years, from profiling pancreas disease states to identifying molecular mechanisms of therapy resistance in pancreatic ductal adenocarcinoma, a particularly deadly cancer. Single-cell transcriptomics and related spatial approaches have identified previously undescribed epithelial and stromal cell types and states, how these populations change with disease progression, and potential mechanisms of action which will serve as the basis for designing new therapeutic strategies. Here, we review the recent literature on how single-cell transcriptomic approaches have changed our understanding of pancreas biology and disease progression.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 30, 2023
- Source ID
- 10.1136/gutjnl-2022-329313
Entities
People
- Amelia Cephas
- Anirban Maitra
- Kathleen E DelGiorno
- Oren Parnas
- William L. Hwang
Organizations
- American Gastroenterological Association
- Burroughs Wellcome Fund
- Israel Cancer Research Fund
- Israel Science Foundation
- National Cancer Institute
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of General Medical Sciences
- The University of Texas MD Anderson Cancer Center
- United States Department of Defense