Circadian Clock Control of Hepatic Lipid Metabolism: Role of Small Heterodimer Partner (Shp)
Abstract
Hepatic steatosis, the accumulation of triglyceride droplets in the hepatocytes, is a common hepatic pathology seen in subjects with obesity/metabolic syndrome and those with excessive alcohol use. The pathogenesis underlying hepatic steatosis is complex. Recent studies have shown the specific role played by the molecular clock mechanism in the control of lipid metabolism and that the disruption of these tissue clocks may lead to the disturbances in lipid homeostasis. This review reports a novel role of small heterodimer partner in maintaining triglyceride and lipoprotein homeostasis through neuronal PAS domain protein 2.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 01, 2016
- Source ID
- 10.1136/jim-2016-000194
Entities
People
- Li Wang
- Suthat Liangpunsakul
Organizations
- Indiana University
- Indiana University School of Medicine
- National Institutes of Health
- United States Department of Defense
- United States Department of Veterans Affairs
- University of Connecticut
- Wenzhou Medical University
- Yale University