Alcohol and Fat Promote Steatohepatitis: A Critical Role for Fat-Specific Protein 27/Cidec
Abstract
Alcoholic liver disease (ALD) is a major public health problem worldwide and is the leading cause of end-stage liver disease. While the ultimate control of ALD will require the prevention of alcohol abuse, better understanding of the mechanisms of alcohol-induced liver injury may lead to treatments of fatty liver, alcoholic hepatitis, and prevention or delay of occurrence of cirrhosis. The elucidation and the discovery of several new concepts in ALD pathogenesis have raised our understanding on the complex mechanisms and the potential in developing the new strategies for therapeutic benefits. In this review, we provide the most up-to-date information on the basic molecular mechanisms focusing on the role of fat-specific protein 27/CIDEC in the pathogenesis of ALD.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 01, 2016
- Source ID
- 10.1136/jim-2016-000204
Entities
People
- Bin Gao
- Suthat Liangpunsakul
Organizations
- Indiana University
- Indiana University School of Medicine
- National Institutes of Health
- United States Department of Defense
- United States Department of Veterans Affairs