Role of Hepatic Macrophages in Alcoholic Liver Disease
Abstract
Alcohol consumption can lead to the increase in gut permeability and cause the translocation of bacteria-derived lipopolysaccharides from the gut to the liver, which subsequently activates immune responses. In this process, macrophages play a critical role and involve in the pathogenesis of alcoholic liver disease (ALD). To define the mechanism underpinning the function of macrophages, it is important to conduct extensive studies to further explicate the phenotypic diversity of macrophages in the context of ALD. In this review, the role of hepatic macrophages in the pathogenesis of ALD is discussed.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 01, 2016
- Source ID
- 10.1136/jim-2016-000210
Entities
People
- Cynthia Ju
- Suthat Liangpunsakul
Organizations
- Indiana University School of Medicine
- National Institutes of Health
- United States Department of Defense
- United States Department of Veterans Affairs
- University of Colorado