Combination of a novel heat shock protein 90-targeted photodynamic therapy with PD-1/PD-L1 blockade induces potent systemic antitumor efficacy and abscopal effect against breast cancers
Abstract
We previously demonstrated potent antitumor activity against human breast cancer xenografts using photodynamic therapy (PDT) targeting a novel tumor-specific photosensitizer (HS201), which binds heat shock protein 90 (HS201-PDT). However, induction of systemic antitumor immunity by HS201-PDT alone or by the combination strategy with immune checkpoint blockade has yet to be determined.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 01, 2022
- Source ID
- 10.1136/jitc-2022-004793
Entities
People
- Amy Hobeika
- Chaitanya Acharya
- Herbert Kim Lyerly
- Hiroshi Nagata
- Kensuke Kaneko
- Michael A. Morse
- Philip F. Hughes
- Takuya Osada
- Timothy A. J. Haystead
- Yang Xiao
- Zachary C Hartman
Organizations
- United States Department of Defense