Tumorous expression of NAC1 restrains antitumor immunity through the LDHA-mediated immune evasion
Abstract
T cell-mediated antitumor immunity has a vital role in cancer prevention and treatment; however, the immune-suppressive tumor microenvironment (TME) constitutes a significant contributor to immune evasion that weakens antitumor immunity. Here, we explore the relationship between nucleus accumbens-associated protein-1 (NAC1), a nuclear factor of the BTB (broad-complex, Tramtrack, bric a brac)/POZ (Poxvirus, and Zinc finger) gene family, and the TME.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 01, 2022
- Source ID
- 10.1136/jitc-2022-004856
Entities
People
- Anil Kumar
- Darby Balllard
- Hao-yun Peng
- Jianxun Song
- Jin-ming Yang
- Jugal K Das
- Liqing Wang
- Xiaofang Xiong
- Xingcong Ren
- Yi Zhang
- Yijie Ren
Organizations
- National Institutes of Health
- United States Department of Defense