Acute graft-versus-host disease following lung transplantation in a patient with a novel TERT mutation
Abstract
Familial pulmonary fibrosis is associated with loss-of-function mutations in telomerase reverse transcriptase (TERT) and short telomeres. Interstitial lung diseases have become the leading indication for lung transplantation in the USA, and recent data indicate that pathogenic mutations in telomerase may cause unfavourable outcomes following lung transplantation. Although a rare occurrence, solid organ transplant recipients who develop acute graft-versus-host disease (GVHD) have very poor survival. This case report describes the detection of a novel mutation in TERT in a patient who had lung transplantation for familial pulmonary fibrosis and died from complications of acute GVHD.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 30, 2018
- Source ID
- 10.1136/thoraxjnl-2017-211121
Entities
People
- Alexandre T Vessoni
- Amy Musiek
- Brian S Kim
- Chad A Witt
- Chang Liu
- Cylen Javidan-nejad
- Dayna S Early
- Dennis M Balfe
- Derek E. Byers
- Elbert P Truclock
- Geoffrey L. Uy
- George J Despotis
- Ilana S Rosman
- Ina Amarillo
- Jennifer K. Sehn
- John DiPersio
- Jonathan R Brestoff
- Jonathan W Heusel
- Kirsten A Brenner
- Lingxin Zhang
- Luis F Z Batista
- Lukas D Wartman
- Marianna B Ruzinova
- Milan J Anadkat
- Morey Blinder
- Ramsey R Hachem
- Roger D Yusen
- Wojcieh Swat
Organizations
- American Federation for Aging Research
- Edward Mallinckrodt Jr. Foundation
- Longer Life Foundation
- National Heart, Lung, and Blood Institute
- United States Department of Defense
- V Foundation for Cancer Research