Pulmonary fibrosis 4 months after COVID-19 is associated with severity of illness and blood leucocyte telomere length
Abstract
The risk factors for development of fibrotic-like radiographic abnormalities after severe COVID-19 are incompletely described and the extent to which CT findings correlate with symptoms and physical function after hospitalisation remains unclear. At 4 months after hospitalisation, fibrotic-like patterns were more common in those who underwent mechanical ventilation (72%) than in those who did not (20%). We demonstrate that severity of initial illness, duration of mechanical ventilation, lactate dehydrogenase on admission and leucocyte telomere length are independent risk factors for fibrotic-like radiographic abnormalities. These fibrotic-like changes correlate with lung function, cough and measures of frailty, but not with dyspnoea.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 29, 2021
- Source ID
- 10.1136/thoraxjnl-2021-217031
Entities
People
- Belinda M D'souza
- Christine Kim Garcia
- Claire McGroder
- David Zhang
- Eric A. Hoffman
- Mary M Salvatore
- Matthew R Baldwin
- Mohammad A Choudhury
- Ying Wei
Organizations
- National Institutes of Health
- United States Department of Defense